Wednesday, September 30, 2026 · continued — 270–339 of 640
Purchase of 1,924 shares at $75.5151 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409116 · filed 2026-09-30 · View filing →
Purchase of 40,081 shares at $3.59 per share.
Reporting Person TANNENBAUM LEONARD M · Transaction Code P
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001628280-26-064003 · filed 2026-09-30 · View filing →
Sale of 891 shares at $161.4885 per share.
Reporting Person HERSHEY TRUST CO TRUSTEE IN TRUST FOR MILTON HERSHEY SCHOOL · Transaction Code S
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000950142-26-002643 · filed 2026-09-30 · View filing →
Purchase of 1,699 shares at $82.6822 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409118 · filed 2026-09-30 · View filing →
Purchase of 1,672 shares at $81.8162 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409118 · filed 2026-09-30 · View filing →
Acquisition (code A) of 27,000 shares at $5.04 per share.
Reporting Person MCDONALD COLLEEN J · Officer Title CFO · Transaction Code A
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001663450-26-000008 · filed 2026-09-30 · View filing →
Sale of 685 shares at $197.48 per share.
Reporting Person Komin Robert Patrick Jr. · Officer Title Chief Financial Officer · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001628280-26-064044 · filed 2026-09-30 · View filing →
Sale of 839 shares at $160.8487 per share.
Reporting Person HERSHEY TRUST CO TRUSTEE IN TRUST FOR MILTON HERSHEY SCHOOL · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000950142-26-002643 · filed 2026-09-30 · View filing →
Disposition (code F) of 26,765 shares at $5.04 per share.
Reporting Person HOFFMAN LLOYD · Officer Title CEO AND PRESIDENT · Transaction Code F
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001258134-26-000007 · filed 2026-09-30 · View filing →
Sale of 598 shares at $212.93 per share.
Reporting Person Mallick Dhiraj · Officer Title Chief Operating Officer · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001628280-26-064042 · filed 2026-09-30 · View filing →
Purchase of 523 shares at $238.799 per share.
Reporting Person Conifer Management, L.L.C. · Transaction Code P
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000905148-26-004310 · filed 2026-09-30 · View filing →
Purchase of 2,789 shares at $44.5085 per share.
Reporting Person Nechmad Yair · Officer Title CEO, Co Founder & Chairman · Transaction Code P
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001976408-26-000874 · filed 2026-09-30 · View filing →
Sale of 600 shares at $205.47 per share.
Reporting Person Komin Robert Patrick Jr. · Officer Title Chief Financial Officer · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001628280-26-064044 · filed 2026-09-30 · View filing →
Purchase of 1,416 shares at $85.8855 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409127 · filed 2026-09-30 · View filing →
Sale of 459 shares at $254.79 per share.
Reporting Person Kurtz George · Officer Title PRESIDENT AND CEO · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001778564-26-000175 · filed 2026-09-30 · View filing →
Sale of 460 shares at $251.76 per share.
Reporting Person Kurtz George · Officer Title PRESIDENT AND CEO · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001778564-26-000175 · filed 2026-09-30 · View filing →
Sale of 9,545 shares at $11.9788 per share.
Reporting Person Chard Daniel R · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001628280-26-064063 · filed 2026-09-30 · View filing →
Sale of 9,544 shares at $11.73 per share.
Reporting Person Chard Daniel R · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001628280-26-064063 · filed 2026-09-30 · View filing →
Sale of 21,943 shares at $5.04 per share.
Reporting Person MONTGOMERY CHARLES D · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001347444-26-000008 · filed 2026-09-30 · View filing →
Sale of 635 shares at $163.2863 per share.
Reporting Person HERSHEY TRUST CO TRUSTEE IN TRUST FOR MILTON HERSHEY SCHOOL · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000950142-26-002643 · filed 2026-09-30 · View filing →
Sale of 1,000 shares at $102.19530 per share.
Reporting Person LARSON KEITH R · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001437749-26-031545 · filed 2026-09-30 · View filing →
Purchase of 1,195 shares at $85.4030 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409127 · filed 2026-09-30 · View filing →
Sale of 3,961 shares at $25.26 per share.
Reporting Person Bergman Artur · Officer Title Chief Technology Officer · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001517413-26-000300 · filed 2026-09-30 · View filing →
Purchase of 10,249 shares at $9.6600 per share.
Reporting Person TEACHERS INSURANCE & ANNUITY ASSOCIATION OF AMERICA · Transaction Code P
Traded May 12, 2026 · Disclosed Sep 30, 2026FILED +141 DAYS
Source: SEC Form 4 · 0001225208-26-008002 · filed 2026-09-30 · View filing →
Acquisition (code A) of 616 shares at $160.72 per share.
Reporting Person CRIST PETER D · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001244272-26-000008 · filed 2026-09-30 · View filing →
Sale of 200 shares at $486.77 per share.
Reporting Person ROTHBLATT MARTINE A · Officer Title Chairperson & CEO · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001106578-26-000152 · filed 2026-09-30 · View filing →
Purchase of 1,167 shares at $83.1552 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409118 · filed 2026-09-30 · View filing →
Sale of 382 shares at $249.81 per share.
Reporting Person Kurtz George · Officer Title PRESIDENT AND CEO · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001778564-26-000175 · filed 2026-09-30 · View filing →
Sale of 1,005 shares at $92.40 per share.
Reporting Person Grosh Chasity D · Officer Title See Remarks · Transaction Code S
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409201 · filed 2026-09-30 · View filing →
Disposition (code F) of 74,370 shares at $1.18 per share.
Reporting Person Martell Frank · Officer Title Chief Executive Officer · Transaction Code F
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409090 · filed 2026-09-30 · View filing →
Purchase of 1,044 shares at $81.3139 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409118 · filed 2026-09-30 · View filing →
Purchase of 957 shares at $86.8142 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409127 · filed 2026-09-30 · View filing →
Sale of 300 shares at $276.68 per share.
Reporting Person BIDZOS D JAMES · Officer Title Exec. Chairman, Pres, & CEO · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001204816-26-000049 · filed 2026-09-30 · View filing →
Purchase of 1,024 shares at $81.0204 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409118 · filed 2026-09-30 · View filing →
Purchase of 1,027 shares at $80.5200 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409118 · filed 2026-09-30 · View filing →
Disposition (code F) of 16,059 shares at $5.04 per share.
Reporting Person MCDONALD COLLEEN J · Officer Title CFO · Transaction Code F
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001663450-26-000008 · filed 2026-09-30 · View filing →
Sale of 400 shares at $201.96 per share.
Reporting Person Komin Robert Patrick Jr. · Officer Title Chief Financial Officer · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001628280-26-064044 · filed 2026-09-30 · View filing →
Sale of 315 shares at $256.42 per share.
Reporting Person Kurtz George · Officer Title PRESIDENT AND CEO · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001778564-26-000175 · filed 2026-09-30 · View filing →
Acquisition (code M) of 10,000 shares at $7.89 per share.
Reporting Persons RA CAPITAL MANAGEMENT, L.P. · RA Capital Healthcare Fund LP · RA Capital Nexus Fund, L.P. · RA Capital Nexus Fund II, L.P. · RA Capital Nexus Fund III, L.P. · Kolchinsky Peter · Shah Rajeev M. · Transaction Code M
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001231919-26-001416 · filed 2026-09-30 · View filing →
Purchase of 93,091 shares at $0.84 per share.
Reporting Person Barry Richard · Officer Title President & CEO · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001437749-26-031597 · filed 2026-09-30 · View filing →
Purchase of 320 shares at $243.8588 per share.
Reporting Person Conifer Management, L.L.C. · Transaction Code P
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000905148-26-004310 · filed 2026-09-30 · View filing →
Sale of 160 shares at $479.59 per share.
Reporting Person ROTHBLATT MARTINE A · Officer Title Chairperson & CEO · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001106578-26-000152 · filed 2026-09-30 · View filing →
Acquisition (code A) of 15,000 shares at $5.04 per share.
Reporting Person Millar Donna · Transaction Code A
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001726903-26-000006 · filed 2026-09-30 · View filing →
Acquisition (code A) of 470 shares at $160.72 per share.
Reporting Person KENNEY BRIAN A · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001020076-26-000008 · filed 2026-09-30 · View filing →
Purchase of 1,056 shares at $71.4843 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409116 · filed 2026-09-30 · View filing →
Sale of 293 shares at $255.99 per share.
Reporting Person Kurtz George · Officer Title PRESIDENT AND CEO · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001778564-26-000175 · filed 2026-09-30 · View filing →
Sale of 481 shares at $154.4515 per share.
Reporting Person Blecharczyk Nathan · Officer Title Chief Strategy Officer · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409120 · filed 2026-09-30 · View filing →
Disposition (code F) of 2,011 shares at $36.12 per share.
Reporting Person Whalen James F. · Transaction Code F
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001419536-26-000154 · filed 2026-09-30 · View filing →
Acquisition (code M) of 2,750 shares at $26.41 per share.
Reporting Person Whalen James F. · Transaction Code M
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001419536-26-000154 · filed 2026-09-30 · View filing →
Acquisition (code A) of 2,224.25 shares at $32.21 per share.
Reporting Person Herbert Cecilia Healy · Transaction Code A
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409161 · filed 2026-09-30 · View filing →
Acquisition (code A) of 439 shares at $160.72 per share.
Reporting Person LEFEVRE DEBORAH L. HALL · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001777925-26-000008 · filed 2026-09-30 · View filing →
Purchase of 884 shares at $79.7076 per share.
Reporting Persons BAKER BROS. ADVISORS LP · 667, L.P. · Baker Bros. Advisors (GP) LLC · Baker Brothers Life Sciences LP · BAKER FELIX · BAKER JULIAN · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001193125-26-409118 · filed 2026-09-30 · View filing →
Acquisition (code A) of 434 shares at $160.72 per share.
Reporting Person WASHINGTON ALEX E III · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001814152-26-000008 · filed 2026-09-30 · View filing →
Disposition (code F) of 35,956 shares at $1.90 per share.
Reporting Person Smith Gerald Bartholomew · Officer Title Chief Executive Officer · Transaction Code F
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001104659-26-112447 · filed 2026-09-30 · View filing →
Acquisition (code A) of 420 shares at $160.72 per share.
Reporting Person TEGLIA KARIN GUSTAFSON · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001777967-26-000008 · filed 2026-09-30 · View filing →
Sale of 409 shares at $162.4296 per share.
Reporting Person HERSHEY TRUST CO TRUSTEE IN TRUST FOR MILTON HERSHEY SCHOOL · Transaction Code S
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000950142-26-002643 · filed 2026-09-30 · View filing →
Acquisition (code A) of 412 shares at $160.72 per share.
Reporting Person CONNELLY ELIZABETH H. · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001761744-26-000014 · filed 2026-09-30 · View filing →
Disposition (code F) of 13,057 shares at $5.04 per share.
Reporting Person MONTGOMERY CHARLES D · Transaction Code F
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001347444-26-000008 · filed 2026-09-30 · View filing →
Sale of 256 shares at $256.99 per share.
Reporting Person Kurtz George · Officer Title PRESIDENT AND CEO · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001778564-26-000175 · filed 2026-09-30 · View filing →
Acquisition (code A) of 394 shares at $160.72 per share.
Reporting Person RICHTER DAVID S · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001106469-26-000008 · filed 2026-09-30 · View filing →
Acquisition (code A) of 388 shares at $160.72 per share.
Reporting Person Smith Gregory A · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001366763-26-000008 · filed 2026-09-30 · View filing →
Sale of 82 shares at $748.91 per share.
Reporting Person Olivan Javier · Officer Title Chief Operating Officer · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000950103-26-014886 · filed 2026-09-30 · View filing →
Sale of 82 shares at $748.91 per share.
Reporting Person Olivan Javier · Officer Title Chief Operating Officer · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000950103-26-014886 · filed 2026-09-30 · View filing →
Acquisition (code A) of 361 shares at $160.72 per share.
Reporting Person GLABE MARLA F · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001642693-26-000008 · filed 2026-09-30 · View filing →
Sale of 120 shares at $482.2806 per share.
Reporting Person ROTHBLATT MARTINE A · Officer Title Chairperson & CEO · Transaction Code S
Traded Sep 29, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001106578-26-000152 · filed 2026-09-30 · View filing →
Purchase of 230 shares at $250.3504 per share.
Reporting Person Conifer Management, L.L.C. · Transaction Code P
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000905148-26-004310 · filed 2026-09-30 · View filing →
Sale of 160 shares at $356.9662 per share.
Reporting Person Wang Xiaodong · Transaction Code S
Traded Sep 28, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001662982-26-000004 · filed 2026-09-30 · View filing →
Disposition (code F) of 21,523 shares at $2.65 per share.
Reporting Person McAleenan Kevin · Officer Title Chief Executive Officer · Transaction Code F
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0002052799-26-000013 · filed 2026-09-30 · View filing →
Acquisition (code A) of 354 shares at $160.72 per share.
Reporting Person MCKINNEY SUZET M · Transaction Code A
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0001865855-26-000016 · filed 2026-09-30 · View filing →
Sale of 352 shares at $160.7293 per share.
Reporting Person HERSHEY TRUST CO TRUSTEE IN TRUST FOR MILTON HERSHEY SCHOOL · Transaction Code S
Traded Sep 30, 2026 · Disclosed Sep 30, 2026
Source: SEC Form 4 · 0000950142-26-002643 · filed 2026-09-30 · View filing →